An epidemiologic approach to gene-environment interaction

Epidemiologic and genetic approaches in the study of gene-environment interaction: an overview of available methods.

The interest in conducting studies to examine geneenvironment interaction is increasing for most chronic and complex diseases such as cancer. This increased interest is mostly due to considerable advances in molecular genetic techniques. Gene-environment studies are motivated by different situations including: 1) The detection of major genes that do not have estimated lifetime risks that reach ...

Genetic and epidemiologic approaches to the search for gene-environment interaction: the case of osteoporosis.

From Genotype × Environment Interaction to Gene × Environment Interaction

Historically in plant breeding a large number of statistical models has been developed and used for studying genotype × environment interaction. These models have helped plant breeders to assess the stability of economically important traits and to predict the performance of newly developed genotypes evaluated under varying environmental conditions. In the last decade, the use of relatively low...

Nontraditional epidemiologic approaches in the analysis of gene-environment interaction: case-control studies with no controls!

Although case-control studies are suitable for assessing gene-environment interactions, choosing appropriate control subjects is a valid concern in these studies. The authors review three nontraditional study designs that do not include a control group: 1) the case-only study, 2) the case-parental control study, and 3) the affected relative-pair method. In case-only studies, one can examine the...

Evolving methods in genetic epidemiology. III. Gene-environment interaction in epidemiologic research.

Genetic epidemiology is increasingly focused on the study of common diseases with both genetic and environmental determinants. The concept of geneenvironment interaction is becoming a central theme in epidemiologic studies that assess causes of human disease in populations (1). Advances in genetic technology and the work of the Human Genome Project will make it easier for the study of gene-envi...